Effects Of The Traditional Chinese Medicine In The Different Acting Styles On Glucorticoid Receptor (gr) In Brain Cytosol And Glucocorticoid Receptor Gr In The Thymus During Long Time Progressive Load Training

Por: Bo Chang.

Athens 2004: Pre-olympic Congress

Send to Kindle

In order to study the mechanism of immunosuppression and effects of the traditional Chinese medicine in the different
acting styles on GR in brain cytosol and GR in the thymus during long time progressive load training.

40 male Sprague-Dawley were randomly divided into four groups equally, those were control group, training group,
group 1 administrated by gullet (M1, first invigorate the Spleen method, then tonify the Kidney method, which is called
Xu Guan method , In which prescription contains tangshen , largehead attractylodes rhizome , licorice root , medication
information ratio is respectively 1:1:1:1) ; Group 2 administrated by gullet (M2, tonify the Kidney method. In which
prescription contains common monkshood prepared daughter root , Chinese cassia tree , Chinese fox-Glove root ,
Asiatic cornelian cherry fruit , common yam rhizome , bary wolfberry fruit , shorthorned epimedium herb , licrice root ,
medication information ratio is respectively 2: 1: 3: 2: 3: 3: 3: 1 ), medicines were made into herbal medicine that
contains about content of 1g/ml. administrated by gullet according to 10g/kg body weight , one time everyday. Other
groups were administrated by equal volume distilled water. Radioimmunoassay was used to oberserve the effects of 8
week step swimming training, the traditional Chinese medicine in the different acting styles on GR in brain cytosol and
GR in the thymus as well as corticosterone during long time progressive load training.

Investigational results are found that GR content in brain cytosol in T group is significantly lower than that of in control
group (P<0.01). GR content of rat brain cytosol in M1 and M2 groups is higher than that of in T group, but there are no
marked differences between them. In the meanwhile, GR in the thymus cell has a significant decrease in T group
compared with control group. GR in the thymus cell remains apparently elevated in M1 group compared with that of in
T group, and GR in the thymus cell is higher in M2 group than that of in T group, but without significant change. GR
levels between M1 and M2 groups are indistinguishable. Evidence is suggested that long time progressive load training
can diminish GR in brain cytosol that is significantly lower in T group than that of in C group. GR in both M1 and M2
groups is higher than that of in T group, but there are no significant change between them. Moreover, compared with
control group, GR in the thymus decreases distinctly in T group. Furthermore, there is marked increase in M1 group
compare with that of in T group, and GR in the thymus in M2 has more increase than that of in T group, but without
significant changes. Similarly, GR in the thymus is higher in M1 group than in M2 group, and there is significant
difference between them.

Consequence demonstrates that long-term amount of exercise leads to decline of GR in brain cytosol and weakness of
GR sensitivity to glucocorticoid, which bring about feedback function diminution to hypothalamus-pituitary-adrenal
axis (HPAA). In addition, it results in decrease of GR in the thymus, which cuts down body immunization capability
because decline of GR level in the thymus directly affects immune cell mature. All of these perhaps relate to
immunosuppression and upper respirator infection by long-term heavy training. The method by first invigorate the
Speen, then tonify the Kidney may raise amount of GR in the thymus cell and be beneficial to T cell mature and
differentiation. Meanwhile, it reduces glucocorticoid suppression to lymphocytic cells, which improves and enhances
body immunological function.

[1]. Droste SK, Gesing A, Ulbricht S, Muller MB, Linthorst AC, Reul JM. Effects of long-term voluntary exercise on the
mouse hypothalamic-pituitary-adrenocortical axis. Endocrinology. 2003 Jul;144(7):3012-23
[2]. Harfstrand A, Fuxe K, Cintra A. Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9779-83.
[3]. Miller AH, Spencer RL, Pearce BD. Glucocorticoid receptors are differentially expressed in the cells and tissues
of the immune system. Cell Immunol. 1998 May 25;186(1):45-54.
[4]. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M. Brain corticosteroid receptor balance in health and disease.
Endocr Rev. 1998 Jun;19(3):269-301.
[5]. Vacchio MS, Papadopoulos V, Ashwell JD. Steroid production in the thymus: implications for thymocyte selection.
J Exp Med. 1994 Jun 1;179(6):1835-46.
[6]. Denton RR, Eisen LP, Elsasser MS, Harmon JM. Differential autoregulation of glucocorticoid receptor expression
in human T- and B-cell lines. Endocrinology. 1993 Jul;133(1):248-56.
[7].. Gaab J, Huster D, Peisen R,. Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and
health under psychological, physiological, and pharmacological stimulation. Psychosom Med. 2002 Nov-
[8]. Duclos M, Corcuff JB, Pehourcq F, Decreased pituitary sensitivity to glucocorticoids in endurance-trained men.
Eur J Endocrinol. 2001 Apr;144(4):363-8
[9]. ]Willoughby DS, Taylor M, Taylor L. Glucocorticoid receptor and ubiquitin expression after repeated eccentric
exercise. Med Sci Sports Exerc. 2003 Dec;35(12):2023-31.

NOTA: O texto com a iconografia está no anexo.

Ver Arquivo (PDF)




© 1996-2020 Centro Esportivo Virtual - CEV.
O material veiculado neste site poderá ser livremente distribuído para fins não comerciais, segundo os termos da licença da Creative Commons.