Acute Capsaicin Analog Supplementation Improves Maximal Voluntary Isometric Contraction Performance In Healthy Young Men

Introduction: Capsaicin is an active pungent ingredient in chili peppers and various spicy foods. Capsaicin seems to influence a variety of physiological systems including skeletal muscle. Objective: The aim of this study was to investigate the acute effect of capsaicin analog supplementation on maximal voluntary isometric contraction (MVIC) performance in healthy young men. Methods: Thirteen participants (age = 25.2 ± 3.2 y; Body mass = 81.2 ± 13.8 kg) participated in this randomized, double-blind crossover study and completed two trials: capsaicin analog condition [Capsiate (CAP) = 12rng] ora placebo condition. 45 minutes after supplement consumption, the subjects performed five sets of 10 seconds of knee extension maximal voluntary isometric contraction (MVIC) with 45 seconds of recovery between sets in a electronic dynamometer (Power Din Standard; CEFISE, São Paulo, Brazil). The subjects remained seated with the knee flexed to 90°. The MVIC performance was recorded and the sum the five efforts of the peak force (TPF), of the mean force (TMeanF), of the minimum force (TMinF) and of the ares under curve (TAUC) were analyzed. Results: TPF (CAP = 3039.4 ± 511.8 vs placebo = 2899.1 ±423.1 N, p = 0.022) was statistically significant different between conditions and there was a small effect size (d = 0.31, A% = 5). TMeanF was significantly higher in the CAP compared to placebo condition (CAP = 2607 ± 455.8 vs placebo = 2502.2 ± 403.5 N, p= 0.050) and there was a small effect size [d = 0.25, A% = 4). TMinF (CAP = 2028.5 ± 428.5 N vs Placebo = 2050.1 ± 382.2 N, p = 0.839) not significant differences between conditions and there was a negligible effect size (d = 0.06, A% = -1). TAUC was significantly greater in the CAP compared to placebo condition (CAP = 20754.1 ± 3629.4 N.sec vs Placebo = 19918.5 ± 3213.6 N.sec, p = 0.049) and the effect was small [d = 0.25, A% = 4). Conclusion: Capsaicin analog supplementation did improve overall MVIC performance in healthy young men (small effect), but did not change the sum of the five efforts of the minimum force. Agência de Fomento: Fundação deAmparo a Ciência e Tecnologia do Estado de Pernambuco. 

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