Type 2 diabetes mellitus (2DM) is associated with an increased risk of dementia and recent data have re-awoken controversy about potential deleterious effect of recurrent, severe hypoglycemia on cognitive function. Physical exercise (PE) is a non-pharmacology treatment to cardiometabolic diseases and some evidence suggests that it could influence the brain by modulating several mechanisms for the cognition. It remains to be elucidated the key of the development of cognitive impairment in people with 2DM and to establish the beneficial effects of an active lifestyle on the risk of dementia related to 2DM. The aim was to verify association among cognitive function and depressive symptoms, and metabolic and hemodynamic parameters in physically active hypertensive and 2DM elderly women.