Introdução: Placebo é considerado uma substância ou um procedimento inerte que pode proporcionar um efeito positivo ou negativo dependendo da condição em que é aplicado. É bem documentado que o placebo promove resultados positivos em condições patológicas e em condições de desempenho físico. Objetivo: Sendo assim, objetivo desse estudo é revisar em duas sessões, trabalhos que tenham abordado: 1) o efeito placebo e nocebo aplicado à clínica no tratamento da doença de Parkinson, depressão e dor, e 2) o uso do placebo como recurso ergogênico no desempenho físico. Metodologia: Para tal, uma busca foi realizada na base de dados “Pubmed” e “Web of Science”. Resultados e discussão: Nesta revisão narrativa, discutimos como o efeito placebo atua em diversas condições como a dor, depressão, doença de Parkinson, e no desempenho físico, além disso, foram abordados possíveis mecanismos que possam atuar neste fenômeno. Conclusão: Podemos concluir que em condição clínica e de desempenho físico, o placebo compartilha regiões cerebrais semelhantes, que geram respostas positivas ao tratamento.


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