Effect of two hypoxic environment stimuli on erythropoietin and aerobic capacity

Introduction

The purpose of our study was to investigate the effect of hypoxic environment stimuli on serum EPO and TfR, possible indirect detection of r-HuEPO use via blood markers of altered erythropoiesis.

Methods

The subjects were 20 physically fit and healthy male students. They were randomly assigned to three groups as follows: intermittent hypoxia stimuli (IH, n=7), mimic lived high and trained low group (MH, n=5) and control group (C, n=8). This double-blind experiment comprised 4 weeks of training period and 2 weeks of recovery period.

Results

1) EPOs in IH and MH groups were significantly greeter than that before training period on days 3, 17, 22, and 15, 17, 22, 24, and recovery period ((p<0.05). Before, during and recovery period no significantly changes were found in control group. 2) VO2max in IH was significantly increased after training compared with that before training, but HR and La in IH and MH groups during stint exercise were significantly decreased compared with those before training period except the control group.

Conclusions

Although change of EPO and sTfR concentrations were not significantly influenced by training, which can be influenced by simile time of different low O2 concentration and forms, and due to the complication that indirect detection of r-HuEPO use. VO2max can be increased by intermittent hypoxia stimuli combined with exercise, and simile that hypoxic environment combined with exercise to delay recovery of EPO concentration.

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