Effects of compound dosages of anti-sports anemia administration on erythrocyte hemogram and serum epo levels in rats of sport anemia

 

Introduction

Hemoglobin plays a central role in oxygen transport and ability of aerobic metabolism (Pirow, 2003; Page et al., 1998; Hasibeder et al., 1987; Gaudard et al., 2003). Sports anemia is a general state of poor sports ability in athletes during sports training (Mechrefe et al., 1997; Kluger et al., 1993). The purpose of this paper was to find effective methods of nutrition in the prevention and treatment of sports anemia.

Methods

Male Wistar rats were randomly assigned to three groups: sedentary (S), exercise (E) and exercise + nutrition (EN). The "Compound Dosages of Anti-Sports Anemia" include gen-seng, barrenwort, medlar, heme iron, lycopene, vitamin E and vitamin C, etc. After success of establishing a rat model of sports anemia based on long-term treadmill exercise of progressive loading, effects of "Compound Dosages of Anti-Sports Anemia" administration on erythrocyte hemogram and serum EPO levels were investigated. Serum EPO concentration was quantified by enzyme-linked immunosorbent assay (ELISA) of rats.

Results

The results of the experiment indicated that Hemoglobin (Hb), red blood cell (RBC) and haematocrit (Hct) levels significantly increased respectively (P<0.05) after the "Compound Dosages of Anti-Sports Anemia" administration, but serum EPO did not express significantly difference between groups (P>0.05).

Discussion/Conclusions

The results suggested that "Compound Dosages of Anti-Sports Anemia" is an effective method in the prevention and treatment of sport anemia in rats, however increase of serum EPO levels and enhancement of hematopoiesis in marrow is not the inner mechanism. In addition, the detailed function of the compound dosages on sports anemia is pending investigated.

 

References

[1].    Pirow R.. (2003). Adv Exp Med Biol. 510:101-107.

[2].    Page TC, Light WR, McKay CB, et al. (1998). Microvasc Res. 55(1):54-64.

[3].    Hasibeder W, Schobersberger W, Mairbaurl H. (1987). Int J Sports Med. 8(2):105-108.

[4].    Gaudard A, Varlet-Marie E, Bressolle F, et al. (2003). Sports Med. 33(3):187-212.

[5].    Mechrefe A, Wexler B, Feller E. (1997). Med Health R I. 80(7):216-218.

[6].    Kluger MJ, Ashton HA, Doshi JB, et al. (1993). Med Sci Sports Exerc. 25(2):303-304.