Impact of Omega 3 fatty acids on different organs of SOFA score involved in sepsis

Sepsis is a critical condition which adversely influences majority of populations regardless of any underlying health problems. In 2017, 48.9 million sepsis cases and 11 million its related deaths were estimated, which was noted for almost 20% of deaths worldwide. According to sepsis 3 definition “Sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection”. Severity of organ dysfunction has been assessed with various scoring systems that quantify abnormalities according to clinical findings, laboratory data, or therapeutic intervention. “Organ dysfunction can be identified as an acute change in total Sequential Organ Failure Assessment (SOFA) scores, 2 points or more consequent to the infection”. The hallmark symptom of sepsis is inflammation which is characterized by mitochondrial dysfunction, oxidative stress, and inflammatory cytokine release, and leads to cellular damage and organ dysfunction. “Omega-3 FAs” are the vital component of cell membranes, biotransformed to eicosanoids and other lipid derived substances that control several biochemical processes, such as inflammation and immune response in the body