O Treinamento de Resistência Reverte a Resistência à Insulina de Ratos com Periodontitis

Resumo

O objetivo do presente estudo foi avaliar os efeitos do treinamento de resistência (TR) na glicemia, insulinemia, sensibilidade à insulina, sinalização à insulina (SI) e níveis de fator de necrose tumoral-α (TNF-α) em ratos com periodontite. 40 ratos Wistar machos foram distribuidos em 4 grupos: grupo controle sedentário (SCN), grupo controle exercitado (ExCN), grupo doença periodontal induzida por ligadura sedentária (SPD) e grupo doença periodontal induzida por ligadura exercitada (ExPD). 28 dias após a indução da periodontite iniciou a RT (14 semanas). Glicemia, insulina, níveis de TNF-α e sensibilidade à insulina foram analisados usando vários métodos. IS foi avaliado medindo pp185 com tirosina fosforilada em tecidos sensíveis à insulina (método de western blot). Níveis mais elevados de insulina, HOMA-IR e TNF-α e diminuição da sensibilidade à insulina foram observados no grupo SPD, que também apresentou diminuição dos níveis de tirosina fosforilada por insulina estimulada em pp185 no músculo e tecido adiposo, quando comparado aos outros grupos. O grupo ExPD apresentou níveis aumentados de pp185 tirosina fosforilada estimulada por insulina em comparação ao grupo SPD, mas não apresentou diferença significativa quando comparado aos grupos SCN e ExCN. A RT reverteu as alterações de RI e SI em ratos com periodontite induzida e também diminuiu os níveis de insulina e TNF-α. Portanto, os resultados mostram a importância do TR na prevenção ou reversão da RI em ratos com periodontite.

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[Nepalíes en la cumbre del K2: de porteadores a héroes]

Article (English)

Publicado
2021-02-13
Como Citar
Mota, M. S. de O. da, Mattera, M. S. de L. C., Tsosura, T. V. S., Chiba, F. Y., Pereira, R. F., Bonilha, J. C., Ervolino, E., Belardi, B. E., Santos, R. M. dos, Tavares, B. S., Dourado, N. G., Carnevalli, A. C. N., Santelli, J. O., Sampaio, H. M., Oliveira, R. A. F. de, & Matsushita, D. H. (2021). O treinamento de resistência reverte a resistência à insulina de ratos com periodontitis. Lecturas: Educación Física Y Deportes, 25(273), 97-113. https://doi.org/10.46642/efd.v25i273.2371
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v. 25 n. 273 (2021)
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