Pandemia de covid-19, aptidão física e desfechos de saúde em pessoas idosas com hipertensão: um estudo longitudinal
Por Eduardo Caldas Costa (Autor), Rodrigo Alberto Vieira Browne (Autor), Maria Beatriz da Fonseca-Araújo (Autor), Gabriel Costa Souto (Autor), Ludmila Lucena Pereira Cabral (Autor), Bruno Erick Barros Lucena (Autor).
Em Revista Brasileira de Atividade Física & Saúde - RBAFS v. 31, 2026.
Resumo
Este estudo examinou as mudanças em desfechos relacionados à saúde cardiovascular, comportamentos de movimento e composição corporal em pessoas idosas com hipertensão após 15 meses do início da pandemia de covid-19. Métodos: Quinze pessoas idosas foram incluídas neste estudo longitudinal com acompanhamento de 15 meses. As avaliações incluíram estrutura e função cardíaca, marcadores de saúde vascular (rigidez arterial, função endotelial e espessura médio-íntimal da carótida), pressão arterial de 24 horas e variabilidade da frequência cardíaca, aptidão cardiorrespiratória, atividade física (AF) e comportamento sedentário (CS) avaliados por acelerometria e composição corporal. Modelos lineares generalizados de efeitos mistos foram utilizados para a análise dos dados. Resultados: Após 15 meses, os participantes apresentaram aumento significativo do CS (β = 41 min/dia; p = 0,007), redução da AF de intensidade leve (β = ‒39 min/dia; p = 0,008), diminuição da contagem de passos (β = ‒1.343 passos/dia; p = 0,002) e redução do consumo máximo de oxigênio (β = ‒1,7 mL/kg/min; p = 0,034). Observou-se também uma pequena, porém significativa, redução na espessura da parede posterior do ventrículo esquerdo (β = ‒0,5 mm; p = 0,046). Não foram encontradas alterações significativas nos demais desfechos (p > 0,05). Conclusão: Alterações deletérias nos comportamentos de movimento e na aptidão cardiorrespiratória foram observadas 15 meses após o início da pandemia de Covid-19 em pessoas idosas com hipertensão, apesar da ausência de mudanças significativas em uma gama mais ampla de desfechos relacionados à saúde cardiovascular.
Referências
1. Roth GA, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1736–88. DOI: https://doi.org/10.1016/S0140-6736(18)32203-7
2. Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223–37. DOI: https://doi.org/10.1038/s41581-019-0244-2
3. Yamada Y, Uchida T, Ogino M, Ikenoue T, Shiose T, Fukuma S. Changes in older people’s activities during the coronavirus disease 2019 pandemic in Japan. J Am Med Dir Assoc. 2020;21(10):1387–8.e1. DOI: https://doi.org/10.1016/j.jamda.2020.07.039
4. Browne RAV, Macêdo GAD, Cabral LLP, Oliveira GTA, Vivas A, Fontes EB, et al. Initial impact of the COVID-19 pandemic on physical activity and sedentary behavior in hypertensive older adults: an accelerometer-based analysis. Exp Gerontol. 2020;142:111121. DOI: https://doi.org/10.1016/j.exger.2020.111121
5. Browne RAV, Cabral LLP, Freire YA, Macêdo GAD, Oliveira GTA, Vivas A, et al. Housing type is associated with objectively measured changes in movement behavior during the COVID-19 pandemic in older adults with hypertension: an exploratory study. Arch Gerontol Geriatr. 2021;94:104354. DOI: https://doi.org/10.1016/j.archger.2021.104354
6. Park SK, Park S, Jee YS. Effects of physical inactivity behavior during COVID-19 pandemic on physical fitness, body composition, inflammatory cytokine, and immunocytes in older adults: a retrospective and prospective study. Physiol Behav. 2024;284:114640. DOI: https://doi.org/10.1016/j.physbeh.2024.114640
7. Ross R, Blair SN, Arena R, Church TS, Després J-P, Franklin BA, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign. Circulation. 2016;134(24):e653–e699. DOI: https://doi.org/10.1161/CIR.0000000000000461
8. Beydoun HA, Beydoun MA, Gautam RS, Alemu BT, Weiss J, Hossain S, et al. COVID-19 pandemic impact on trajectories in cardiometabolic health, physical activity, and functioning among adults from the 2006–2020 Health and Retirement Study. J Gerontol A Biol Sci Med Sci. 2022;77(7):1371–9. DOI: https://doi.org/10.1093/gerona/glac028
9. Freiberg A, Schubert M, Romero Starke K, Hegewald J, Seidler A. A rapid review on the influence of COVID-19 lockdown and quarantine measures on modifiable cardiovascular risk factors in the general population. Int J Environ Res Public Health. 2021;18(16):8567. DOI: https://doi.org/10.3390/ijerph18168567
10. Dalton-Alves F, Araújo MBF, Lucena BE, Souto GC, Lopes DSD, Lucena MIS, et al. Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study): study protocol for a randomised trial. BMJ Open. 2024;14(12):e084736. DOI: https://doi.org/10.1136/bmjopen-2024-084736
11. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1–39.e14. DOI: https://doi.org/10.1016/j.echo.2014.10.003
12. Malachias MVB, Souza WKSB, Plavnik FL, Rodrigues CIS, Brandão AA, Neves MFT, et al. 7th Brazilian guideline of arterial hypertension: presentation. Arq Bras Cardiol. 2016;107(3):1–83.
13. Nobre F, Mion D Jr, Gomes MAN, Malachias MVB, Amodeo C. V guidelines for ambulatory blood pressure monitoring (ABPM) and III guidelines for home blood pressure monitoring (HBPM). J Bras Nefrol. 2011;33(3):365–88.
14. Marek Malik, J. Thomas Bigger, A. John Camm, Robert E. Kleiger, Alberto Malliani, Arthur J. Moss. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Eur Heart J. 1996;17(3):354–81. DOI: https://doi.org/10.1093/oxfordjournals.eurheartj.a014868
15. Reference Values for Arterial Stiffness Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: establishing normal and reference values. Eur Heart J. 2010;31(19):2338–50. DOI: https://doi.org/10.1093/eurheartj/ehq165
16. Papaioannou TG, Karageorgopoulou TD, Sergentanis TN, Protogerou AD, Psaltopoulou T, Sharman JE, et al. Accuracy of commercial devices and methods for noninvasive estimation of aortic systolic blood pressure: a systematic review and meta-analysis of invasive validation studies. J Hypertens. 2016;34(7):1237–48. DOI: https://doi.org/10.1097/HJH.0000000000000921
17. Weber T, Wassertheurer S, Rammer M, Maurer E, Hametner B, Mayer CC, et al. Validation of a brachial cuff-based method for estimating central systolic blood pressure. Hypertension. 2011;58(5):825–32. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.111.176313
18. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension. 2010;55(5):1075–85. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.150821
19. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128(8):873–934. DOI: https://doi.org/10.1161/CIR.0b013e31829b5b44
20. Trost SG, McIver KL, Pate RR. Conducting accelerometer-based activity assessments in field-based research. Med Sci Sports Exerc. 2005;37(Suppl):S531–S543. DOI: https://doi.org/10.1249/01.mss.0000185657.86065.98
21. Choi L, Liu Z, Matthews CE, Buchowski MS. Validation of accelerometer wear and nonwear time classification algorithm. Med Sci Sports Exerc. 2011;43(2):357–64. DOI: https://doi.org/10.1249/MSS.0b013e3181ed61a3
22. Freedson PS, Melanson E, Sirard J. Calibration of the Computer Science and Applications, Inc. accelerometer. Med Sci Sports Exerc. 1998;30(5):777–81. DOI: https://doi.org/10.1097/00005768-199805000-00021
23. Alves CPL, Câmara M, Macêdo GAD, Freire YA, de Melo Silva R, Paulo-Pereira R, et al. Agreement between upper and lower limb measures to identify older adults with low skeletal muscle strength, muscle mass and muscle quality. PLoS One. 2022;17(1):e0262732. DOI: https://doi.org/10.1371/journal.pone.0262732
24. Massarotto RJ, Campbell AJ, Kreiter E, Claydon VE, Cote AT. Effects of detraining on left ventricular mass in endurance-trained individuals: a systematic review and meta-analysis. Eur J Prev Cardiol. 2024;31(4):415–24. DOI: https://doi.org/10.1093/eurjpc/zwad327
25. Howden EJ, Sarma S, Lawley JS, Opondo M, Cornwell WK, Stoller D, et al. Reversing the cardiac effects of sedentary aging in middle age: a randomized controlled trial. Circulation. 2018;137(15):1549–1560. DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.030617
26. Toba A, Ishikawa J, Harada K. Ambulatory blood pressure is associated with left ventricular geometry after 10 years in hypertensive patients with continuous antihypertensive treatment. Hypertens Res. 2025;48(1):212–22. DOI: https://doi.org/10.1038/s41440-024-01905-2
27. Laurent S, Boutouyrie P. Arterial stiffness and hypertension in the elderly. Front Cardiovasc Med. 2020;7. DOI: https://doi.org/10.3389/fcvm.2020.544302
28. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011;120(9):357–375. DOI: https://doi.org/10.1042/CS20100476
29. Tanaka H, Palta P, Folsom AR, Meyer ML, Matsushita K, Evenson KR, et al. Habitual physical activity and central artery stiffening in older adults. J Hypertens. 2018;36(9):1889–94. DOI: https://doi.org/10.1097/HJH.0000000000001782
30. Cabral LLP, Freire YA, Browne RAV, Macêdo GAD, Câmara M, Schwade D, et al. Associations of steps per day and peak cadence with arterial stiffness in older adults. Exp Gerontol. 2022;157:111628. 8 DOI: https://doi.org/10.1016/j.exger.2021.111628
31. Liang C, Song Z, Yao XZ, Xiao Q, Fu H, Tang L, et al. Exercise interventions for the effect of endothelial function in hypertensive patients: a systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2024;26(6):599–614. DOI: https://doi.org/10.1111/jch.14818
32. Cameron AC, Lang NN, Touyz RM. Drug treatment of hypertension: focus on vascular health. Drugs. 2016;76(16):1529–50. DOI: https://doi.org/10.1007/s40265-016-0642-8
33. Silva IVG, de Figueiredo RC, Rios DRA. Effect of different classes of antihypertensive drugs on endothelial function and inflammation. Int J Mol Sci. 2019;20(14):3458. DOI: https://doi.org/10.3390/ijms20143458
34. Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension. 2018;71(6):1269–1324. DOI: https://doi.org/10.1161/HYP.0000000000000066
35. Feitosa FGAM, Feitosa ADM, Paiva AMG, Mota-Gomes MA, Barroso WS, Miranda RD, et al. Impact of the COVID-19 pandemic on blood pressure control: a nationwide home blood pressure monitoring study. Hypertens Res. 2022;45(2):364–368. DOI: https://doi.org/10.1038/s41440-021-00784-1
36. Eckberg DL, Kuusela TA. Human vagal baroreflex sensitivity fluctuates widely and rhythmically at very low frequencies. J Physiol. 2005;567(3):1011–19. DOI: https://doi.org/10.1113/jphysiol.2005.091090
37. Thayer JF, Yamamoto SS, Brosschot JF. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol. 2010;141(2):122–31. DOI: