The Effects On Liver Function Of E-antigen Negative Chronic Hepatitis B Carriers After 12 Weeks Walking Training

Introduction
Hepatitis B is commonly found in Taiwan and its prevalence rate is high as well. The percentage of people who have
ever infected by hepatitis B by the age of 30 is 80%, and is near to 100% by the age of 50〔1〕. Presently there are 3
millions of adult who are hepatitis B carriers and these people are potential patients of liver cirrhosis and cancer.
Chronic liver disease and cirrhosis have been the first leading causes of death in Taiwan area. As we all know that
moderate exercise has positive benefits for general population, whether it has the same effect on hepatitis B carriers still
needs to be confirmed. In order to prevent any harmful effect caused by exercising on them, we tried to investigate the
influence of moderate intensity exercise such as walking training to liver function for e-antigen negative chronic
hepatitis B carriers.

Methods
Nineteen male subjects were involved in this study; ten with e-antigen Negative Chronic Hepatitis B
Carriers（hepatitis B group）, and nine of normal health (Control group). The walking training intensity was the heart
rate 130-140 beats/minutes. The frequency of the exercise was three days a week lasted for 12 weeks. Blood samples
were drawn from the subjects previous to their beginning of the exercise (T1) and subsequently four weeks (T2), eight
weeks (T3) and twelve weeks (T4) after completing the exercise.

Results
Ten liver functional values including Direct bilirubin 、Total bilirubin 、AST 、ALT 、Alk-P 、Total
protein、Albumin、Globulin、r-GT and LDH were tested in this study. All values were within normal range at T1, T2,
T3, and T4.

Discussion/Conclusions
The conclusion of the study is that moderate intensity exercise such as 12 weeks of walking has no adverse effect on
liver function to hepatitis B healthy carriers. Nevertheless, the studies on the consequence of exercise to e-antigen
positive chronic hepatitis B carriers have not been done yet. Therefore, it is necessary to make a further investigation
for those e-antigen positive chronic hepatitis B carriers.

References
[1]. Sherlock, S., ＆ Dooley, J.（1997）. Diseases of the liver and biliary system. 10th ed. Blackwell Science Ltd.
London. England.

NOTA: O texto com a iconografia está no anexo

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