A Proteína C Reativa Está Inversa e Independentemente Associada Ao Consumo Máximo de Oxigênio em Adolescentes com Obesidade

Os objetivos deste estudo foram: 1) investigar se diferentes marcadores de inflamação (PCR e TNF-alfa) estão correlacionados à aptidão cardiorrespiratória em adolescentes com obesidade; 2) examinar a associação dessas variáveis ​​quando ajustadas por parâmetros de composição corporal. Foram selecionados 57 indivíduos, 34 meninas e 23 meninos, com 16,4 ± 1,56 anos e índice de massa corporal 36,0 ± 4,3 kg / m2. Foram avaliadas as medidas antropométricas (peso, altura e circunferência abdominal) e a composição corporal (IMC, gordura visceral, gordura corporal). A composição corporal foi estimada por analisador de impedância bioelétrica tetrapolar. Obesidade foi definida como IMC> percentil 95 da curva proposta pelo Center for Diseases Control. O TNF-alfa plasmático foi medido por um imunoensaio enzimático quantitativo de alta sensibilidade em dois locais e a PCR foi medida por meio de alta sensibilidade ensaio imunoturbidimétrico. O teste de esforço máximo graduado foi realizado para obter o consumo máximo de oxigênio (VO2max) e a velocidade associada ao VO2max (vVO2max). Correlações signifi cativas da PCR com o VO2máx e vVO2máx foram encontradas (r = -0,40 er = -0,36, respectivamente). Não foram observadas correlações entre TNF-alfa e VO2máx e vVO2máx. A PCR foi associada ao VO2máx e vVO2máx, independentemente das medidas de composição corporal. A PCR foi associada de forma independente e inversa à medida direta do VO2máx e à variável indireta da aptidão cardiorrespiratória vVO2máx, em adolescentes obesos, mesmo após ajustes na composição corporal, um potencial fator de confusão. Não foi encontrada associação entre o TNF-alfa e os parâmetros de aptidão cardiorrespiratória.

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